New antiviral drugs – including Covid treatments – could be developed from previously overlooked substances found in marine plants, University of the West of Scotland (UWS) research has suggested.
The study looked at a set of substances – a type of carbohydrate that contains sulphur – mainly found in the cell walls of marine algae or seaweeds. It revealed nine of the substances examined show promising results against Covid, with five of the substances never reported as effective before.
Finding valuable biologically active compounds among marine plants shines considerable light on the important role that marine life could play in developing effective antiviral treatments, and a vast amount of these ecosystems are still being discovered.
Professor Milan Radosavljevic, Vice-Principal of Research, Innovation and Engagement at UWS, said: “Despite the advancement of vaccines as a protective measure, the emergence of newly evolved strains of Covid mean that its threat to public health continues, so finding other suitable treatments remains a priority.
“This is a very exciting discovery and shows great potential for these substances to be developed into effective medicines.
“This study highlights our internationally-renowned research expertise, and I am proud of the commitment from our academics and their research students to find solutions to some of the world’s most urgent issues.”
Abdalla Mohamedsalih, a PhD student in the University’s School of Computing, Engineering and Physical Sciences, added: “I’m pleased to be involved in this research, which shows extremely positive results for the future development of antiviral drugs.
“Scientists often look to nature as a potential source for new drug discoveries: for example, the natural environment provided us with penicillin – the first naturally occurring antibiotic to be used therapeutically. Thanks to the development of this drug, various diseases caused by bacteria ceased to be life-threatening.
“I look forward to continuing this research, as we seek to find effective treatments for Covid.”
Researchers at UWS looked at past research papers, spanning 25 years, and focussed on those that mentioned marine plant substances having some effect against different viruses. A shortlist was developed, with 45 substances showing potential antiviral effects: these shortlisted substances came from various marine sources, including different types of algae, microalgae, sea cucumbers, and squid cartilage.